Principal Investigator
Name
Edward Patz
Degrees
MD
Institution
Duke University Medical Center
Position Title
Professor of Radiology
Email
patz0002@mc.duke.edu
Project Information
Study
NLST
Project ID
NLST-427
Title
Evaluation of prevalence of enlarged mediastinal lymph nodes in lung cancer screening population with correlation with lung parenchymal findings and outcome.
Summary
The prevalence of incidental enlarged mediastinal lymph nodes on lung cancer screening CT scans has been reported between 1-6%. Features used to be considered when reporting an abnormal lymph node is 1) size (short axis), 2) density, and 3) FDG activity if available. It has been well documented that metastatic lymph nodes are larger than benign lymph nodes. However, data on size, density, and location of mediastinal adenopathy in correlation with parenchymal findings and outcome in a screened population is lacking. There is also paucity of literature on the clinical importance of incidentally detected large lymph nodes in lung cancer screening population to provide an evidence based guideline for the optimal management of mediastinal adenopathy incidentally found in lung cancer screening population.

Aims
In this project we aim to assess the prevalence of mediastinal adenopathy in lung cancer screening population. We will also correlate the size, density, number and location of lymph nodes with lung parenchymal findings, and outcome to understand the best strategy to follow/manage mediastinal adenopathy in this population.

Collaborators
Hamid Chalian, M.D.
Holman P. McAdams, M.D., FACR
Youkyung Lee, M.D.
Fenghai Duan, PhD.
Edward F. Patz Jr., M.D.

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